4-DBR is financed by the European Union’s Horizon Europe research and innovation programme.
The 4-Deep Brain Reconstruction, 4-DBR consortium aims at generating a brand-new technological approach to regenerate brain affections that occurs in neurological disorders. With 180 million affected people and an economic burden of 798 billion euros/year, Europe needs a radical leap in the future. The complexity of the human brain has condemned every past attempt at regeneration because incomplete technologies did not allow for a full recapitulation of the brain properties and any one of them missing jeopardized the functionality of the whole. There can’t be any incremental solution for brain damage, the technology must be all-in. 4-DBR will focus on developing an implantable 4D reconstructed brain able to recapitulate all brain properties: a complex architecture of neuronal cells integrated in a complete blood circuitry, that will be complemented with an integrated opto-stimulator to induce correct specification and integration of neurons. 4-DBR integrates 6 technological leaders from complementary fields who will unite to develop the components of reconstructed-brains: laser-assisted bioprinting of pre-differentiated neurons with their native decellularized brain matrix, extrusion bioprinting of vascular system, in vitro blood-brain-barrier reconstruction and a tissue integrated wireless-controlled stimulating optoelectrical chip. These 4 components will then be combined into a transplantable reconstructed brain that will be tested in a small animal model of Huntington’s disease. While a first prototype will be delivered in 36 months, the vision unifying 4-DBR expands way further. Therefore, the project will put into action a strong dissemination and exploitation plan: horizontally, 4-DBR will ensure the uptake of the generated methods to strengthen Europe’s technological actors; vertically, 4-DBR will thrust the reconstructed brain approach up in the development ladder to potentially generate in a 10-year span a therapy to change the lives of many patients.
The 4-Deep Brain Reconstruction (4-DBR), a Horizon European Innovation Council (EIC) Pathfinder Open project, aims to develop a conceptually novel brain reconstruction to treat patients who suffer from neurodegenerative disorders.
Due to the complexity of the brain, current approaches and techniques to treat neurodegenerative diseases do not allow for a correct recapitulation of brain properties. Thus, the 4-DBR Consortium will overcome the most frequent limitations encountered in cell-based transplants of dissociated cells and organoids. We aim to develop an implantable 4D bioprinted reconstructed brain able to mimic all properties and functions of the human brain.
Our approach will be able to:
- Overcome the risk of patient rejection of transplants as all our compounds will originate from the patient’s own cells, or they are non-reactive biomaterials.
- Avoid cell death observed in organoids by creating a vascularization system that will feed all cells with necessary oxygen and nutrients.
- Ensure the success of the transplantation by promoting cell maturation selectively once cells are in the desired in vivo target.
- Avoid the unnecessary sacrifice of animals for drug development, as our solution is a more reliable drug testing platform.
The DIOPMA Centre of the University of Barcelona participates in the 4-DBR.
Partners:
Publications:
- In progress…
More information: Elena Xuriguera
Research category: Additive Manufacturing
This project has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No 101047099.